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Neurosurgery Quarterly publishes article on the value of NBS in preoperatively localizing impaired motor cortex in meningioma

08 July 2009

"NBS with TMS would be invaluable for the evaluation of deep-seated motor cortices and deviated unusual thin cortices because there is no indirect method other than NBS for preoperative stimulation."

HELSINKI, Finland--June, 2009--Nexstim Oy, a medical device company developing non-invasive brain diagnostics and therapy technologies, highlights publication of a clinical article and case report "Navigated Brain Stimulation for Preoperative Anatomic" in Neurosurgery Quarterly.

In their discussion, Fujiki et al. conclude that "NBS with TMS would be invaluable for the evaluation of deep-seated motor cortices and deviated unusual thin cortices because there is no indirect method other than NBS for preoperative stimulation. Direct cortical electrical stimulation, even the most straightforward in current modalities, allows only postoperative evaluation of deep-seated motor cortex after tumor removal. Thus, NBS with TMS provides an important new dimension for surgical planning."

In the article abstract, Fujiki et al. summarize that, "Preoperative precise motor cortical mapping using NBS with TMS has the potential to explore anatomic shift and physiologic organization and plastic changes in the human motor system and to establish the degree of remaining functionality in the motor cortex after long-term physical compression and deviation in tumors such as meningioma without implanting electrodes."

Excerpted images and tables can be viewed at this link (scroll pointer over image to open window).

Jukka-Pekka Särkkä, Managing Director of Nexstim commented, " Professor Fujiki was one of the first users of NBS for TMS navigation in clinical neurosurgery and we welcome the publishing of his pioneering clinical work with NBS. This case report clearly demonstrates the value that precise functional mapping can add to structural MR-imaging in preoperative neurosurgical planning."

About NBS in neurosurgery Unlike functional magnetic resonance imaging (fMRI), NBS is a direct method, like DCS, for accurate mapping of the cerebral cortex. DCS is considered the gold standard but it is an invasive technique and can require a large, awake craniotomy. Accurate presurgical maps of the vital functional areas of the cortex, enabled by NBS, allow selection of the optimal treatment strategy for the individual patient, they also save valuable time in the OR and have the potential to enable better patient outcomes.

About Nexstim A "spin-out" company of Helsinki University of Technology, Nexstim was founded in 2000 to commercialize Navigated Brain Stimulation: the combination of MRI-guided transranial magnetic stimulation (TMS) and EMG/EEG measurement. The company has delivered over 40 systems to hospitals in Europe, Japan, Taiwan and USA. Since 2007, Nexstim has raised EUR 14 million in new financing, led by European venture capital investors HealthCap and LSP. See www.nexstim.com.

NBS System is CE-marked. Caution: in the United States the NBS System is limited by Federal law to investigational use.

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